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David Chen

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David Chen

  • College of Science and Technology

    • Biology

      • Assistant Professor

Courses Taught

Number

Name

Level

BIOL 4391

Accelerated Research in Biology

Undergraduate

Selected Publications

Recent

  • Walsh, J.T., Junker, I.P., Chen, Y.D., Chen, Y., Gifford, H., Chen, D.S., & Ding, Y. (2025). High-resolution single-cell analyses reveal evolutionary constraints and evolvability of sexual circuits in Drosophila. Proc Natl Acad Sci U S A, 122(47), e2516083122. United States. 10.1073/pnas.2516083122

  • Duan, Q., Okuwa, S., Estrella, R., Yeung, C., Chen, Y.D., Rio, L.Q., Vien, K.M., & Volkan, P.C. (2025). Deciphering the combinatorial expression pattern and genetic regulatory mechanisms of Beats and Sides in the olfactory circuits of Drosophila. 10.1101/2025.05.31.657193

  • Soffers, J.H., Beck, E., Sytkowski, D.J., Maughan, M.E., Devarakonda, D., Zhu, Y., Wilson, B.A., Chen, Y.D., Erclik, T., Truman, J.W., Skeath, J.B., & Lacin, H. (2025). A library of lineage-specific driver lines connects developing neuronal circuits to behavior in the Drosophila ventral nerve cord. Elife, 14. England. 10.7554/eLife.106042

  • Walsh, J., Junker, I.P., Chen, Y.D., Chen, Y., Gifford, H., & Ding, Y. (2025). High-resolution comparative single-cell transcriptomics of doublesex-expressing neurons reveals evolutionary conservation and diversity of sexual circuits in Drosophila. 10.1101/2025.05.06.652433

  • Carrier, Y., Rio, L.Q., Formicola, N., Sousa-Xavier, V.d., Tabet, M., Chen, Y.D., Ali, A.H., Wislez, M., Orts, L., Borst, A., & Pinto-Teixeira, F. (2025). Biased cell adhesion organizes the Drosophila visual motion integration circuit. Dev Cell, 60(5), 762-779.e7. United States. 10.1016/j.devcel.2024.10.019

  • Holguera, I., Chen, Y., Chen, Y., Simon, F., Gaffney, A., Rodas, J., Córdoba, S., & Desplan, C. (2025). Temporal and Notch identity determine layer targeting and synapse location of medulla neurons. 10.1101/2025.01.06.631439

  • Li, S.A., Li, H.G., Shoji, N., Desplan, C., & Chen, Y.D. (2023). Protocol for replacing coding intronic MiMIC and CRIMIC lines with T2A-split-GAL4 lines in Drosophila using genetic crosses. STAR Protoc, 4(4), 102706. United States. 10.1016/j.xpro.2023.102706

  • Chen, Y.D., Chen, Y., Rajesh, R., Shoji, N., Jacy, M., Lacin, H., Erclik, T., & Desplan, C. (2023). Using single-cell RNA sequencing to generate predictive cell-type-specific split-GAL4 reagents throughout development. Proc Natl Acad Sci U S A, 120(32), e2307451120. United States. 10.1073/pnas.2307451120

  • Chen, Y.D., Chen, Y., Rajesh, R., Shoji, N., Jacy, M., Lacin, H., Erclik, T., & Desplan, C. (2023). Using single-cell RNA sequencing to generate cell-type-specific split-GAL4 reagents throughout development. Cold Spring Harbor Laboratory. doi: 10.1101/2023.02.03.527019.

  • Chen, Y.D., Menon, V., Joseph, R.M., & Dahanukar, A.A. (2021). Control of Sugar and Amino Acid Feeding via Pharyngeal Taste Neurons. J Neurosci, 41(27), 5791-5808. United States. 10.1523/JNEUROSCI.1794-20.2021

  • Choi, B.J., Chen, Y.D., & Desplan, C. (2021). Building a circuit through correlated spontaneous neuronal activity in the developing vertebrate and invertebrate visual systems. Genes Dev, 35(9-10), 677-691. United States. 10.1101/gad.348241.121

  • Chen, Y.D. & Dahanukar, A. (2020). Recent advances in the genetic basis of taste detection in Drosophila. Cell Mol Life Sci, 77(6), 1087-1101. Switzerland. 10.1007/s00018-019-03320-0