David Chen

Profile Picture of David Chen

David Chen

  • College of Science and Technology

    • Biology

      • Assistant Professor

Courses Taught

Number

Name

Level

BIOL 3356

Organization and Development of the Nervous System

Undergraduate

BIOL 4391

Accelerated Research in Biology

Undergraduate

BIOL 5466

Contemporary Biology

Graduate

Selected Publications

Recent

  • Walsh, J.T., Junker, I.P., Chen, Y.D., Chen, Y., Gifford, H., Chen, D.S., & Ding, Y. (2025). High-resolution single-cell analyses reveal evolutionary constraints and evolvability of sexual circuits in Drosophila. Proc Natl Acad Sci U S A, 122(47), e2516083122. United States. 10.1073/pnas.2516083122

  • Duan, Q., Okuwa, S., Estrella, R., Yeung, C., Chen, Y.D., Rio, L.Q., Vien, K.M., & Volkan, P.C. (2025). Deciphering the combinatorial expression pattern and genetic regulatory mechanisms of Beats and Sides in the olfactory circuits of Drosophila. 10.1101/2025.05.31.657193

  • Soffers, J.H., Beck, E., Sytkowski, D.J., Maughan, M.E., Devarakonda, D., Zhu, Y., Wilson, B.A., Chen, Y.D., Erclik, T., Truman, J.W., Skeath, J.B., & Lacin, H. (2025). A library of lineage-specific driver lines connects developing neuronal circuits to behavior in the Drosophila ventral nerve cord. Elife, 14. England. 10.7554/eLife.106042

  • Walsh, J., Junker, I.P., Chen, Y.D., Chen, Y., Gifford, H., & Ding, Y. (2025). High-resolution comparative single-cell transcriptomics of doublesex-expressing neurons reveals evolutionary conservation and diversity of sexual circuits in Drosophila. 10.1101/2025.05.06.652433

  • Carrier, Y., Rio, L.Q., Formicola, N., Sousa-Xavier, V.d., Tabet, M., Chen, Y.D., Ali, A.H., Wislez, M., Orts, L., Borst, A., & Pinto-Teixeira, F. (2025). Biased cell adhesion organizes the Drosophila visual motion integration circuit. Dev Cell, 60(5), 762-779.e7. United States. 10.1016/j.devcel.2024.10.019

  • Holguera, I., Chen, Y., Chen, Y., Simon, F., Gaffney, A., Rodas, J., Córdoba, S., & Desplan, C. (2025). Temporal and Notch identity determine layer targeting and synapse location of medulla neurons. 10.1101/2025.01.06.631439

  • Li, S.A., Li, H.G., Shoji, N., Desplan, C., & Chen, Y.D. (2023). Protocol for replacing coding intronic MiMIC and CRIMIC lines with T2A-split-GAL4 lines in Drosophila using genetic crosses. STAR Protoc, 4(4), 102706. United States. 10.1016/j.xpro.2023.102706

  • Chen, Y.D., Chen, Y., Rajesh, R., Shoji, N., Jacy, M., Lacin, H., Erclik, T., & Desplan, C. (2023). Using single-cell RNA sequencing to generate predictive cell-type-specific split-GAL4 reagents throughout development. Proc Natl Acad Sci U S A, 120(32), e2307451120. United States. 10.1073/pnas.2307451120

  • Chen, Y.D., Chen, Y., Rajesh, R., Shoji, N., Jacy, M., Lacin, H., Erclik, T., & Desplan, C. (2023). Using single-cell RNA sequencing to generate cell-type-specific split-GAL4 reagents throughout development. openRxiv. doi: 10.1101/2023.02.03.527019.

  • Chen, Y.D., Menon, V., Joseph, R.M., & Dahanukar, A.A. (2021). Control of Sugar and Amino Acid Feeding via Pharyngeal Taste Neurons. J Neurosci, 41(27), 5791-5808. United States. 10.1523/JNEUROSCI.1794-20.2021

  • Choi, B.J., Chen, Y.D., & Desplan, C. (2021). Building a circuit through correlated spontaneous neuronal activity in the developing vertebrate and invertebrate visual systems. Genes Dev, 35(9-10), 677-691. United States. 10.1101/gad.348241.121